Liu et al. (2018) suggested TUSC2P was decreased in esophageal squamous cell carcinoma and its downregulation linked to unfavorable prognosis of patients with esophageal squamous cell carcinoma. The inhibitory effects of TUSC2P on proliferation and invasion of esophageal squamous cell carcinoma were also experimentally validated in the study (Liu et al., 2018). TUSC2P-mediated upregulation of TUSC2 was partially responsible for the tumor suppressive roles of TUSC2P in esophageal squamous cell carcinoma (Liu et al., 2018). This evidence concerns the gene TUSC2P1 and esophageal squamous cell carcinoma.