PGA5 and endometrial cancer: Lv et al. (2019) also experimentally confirmed that knockdown of OGFRP1 suppressed the malignant behaviors of endometrial cancer, including suppressed cell viability, enhanced cell apoptosis and inhibited cell migration and invasion. OCT4-pg5 was found to be aberrantly activated in endometrial cancer samples compared with benign endometrium samples, and increased expression of OCT4-pg5 enhanced proliferation by promoting OCT4/PI3K/AKT/CCND1 signaling (Bai et al., 2015).