PTEN and breast carcinoma: For instance, a recent study conducted by Tang et al. (2017a) showed that PTENP1 suppressed proliferation and migration of breast cancer by inhibiting AKT and MAPK signaling pathways; another study performed by Gao et al. (2019) demonstrated that PETNP1 increased expression of PTEN, thus mediating proliferation, invasion and drug resistance of breast cancer by activation of PI3K/AKT pathway.