PTEN and neoplasm: For example, Guo et al. (2016) found that PTENP1 was frequently downregulated in gastric cancer, and suppressed proliferation, migration, invasion and promoted apoptosis of gastric cancer through increasing PTEN expression; Zhang R. et al. (2017) also confirmed the tumor suppressive roles of PTENP1 in gastric cancer by decoying miR-106b and miR-93 and thus upregulating PTEN expression.