Relating these miRNAs with the main molecular deregulated pathways, e.g. the RAS/MAPK pathway, the MITF pathway, the p16INK4A-CDK4-RB pathway, and the PI3K-AKT pathway, would offer new insights in deciphering the aggressive and metastatic feature of melanoma (Segura et al., 2012; Greenberg et al., 2014). The gene discussed is AKT1; the disease is melanoma.