TFAP2A and melanoma: In this direction, miR-214, a pleiotropic molecule, was found deregulated in melanoma, this RNA molecule coordinating important signaling networks (e.g. PTEN/AKT, β-catenin, and tyrosine kinase receptor pathways), gene expression modulators (e.g. Ezh2, p53, and TFAP2), and even other miRNAs like miR-148b.