Aberrant genes associated with melanoma (e.g. NRAS, microphthalmia-associated transcription factor, receptor tyrosine kinase c-KIT, and AP-2 transcription factor) were found linked to the aberrant activation of sets of circulating miRNAs (e.g. let-7a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR-214, miR-221, and miR-222) and can aid the large set of potential biomarkers and/or therapeutic targets in melanoma (Mirzaei et al., 2016). This evidence concerns the gene KIT and melanoma.