An interesting corollary is the high degree of CMC seen patients with Autoimmune Polyendocrine Syndrome Type 1 (APS-1), who produce autoantibodies that neutralize IL-17 cytokines due to mutations in the autoimmune regulator gene (AIRE) (Humbert et al., 2018). The gene discussed is AIRE; the disease is autoimmune polyendocrine syndrome type 1.