A recent international study from 21 countries that comprised 524 families with PALB2 pathogenic variants (PVs) revealed that the estimated relative risk associated with PALB2 PVs for breast cancer in females was 7.18 (95% CI, 5.82–8.85; p = 6.5 × 10−76). The gene discussed is PALB2; the disease is breast carcinoma.