PBRM1 and cancer: Fortunately, there are less significantly mutated genes in ccRCCs compared with other cancers (1); the top four most commonly mutated genes are von Hippel-Lindau (VHL) tumor suppressor gene, polybromo-1 (PBRM1), BRCA1-associated protein 1 (BAP1), and SET domain containing 2 (SETD2) (2, 3).