Mutations in epigenetic factors are frequent in T-ALL: PHF6 (Xq26), SUZ12 (17q11), EZH2 (7q36), TET2 (4q24), H3F3A (1q42), KDM6A (Xp11), EED (11q14), SETD2 (3p21), and DNMT3A (2p23) mutations are the most common (32, 35). Here, DNMT3A is linked to acute lymphoblastic leukemia.