ETV6, RUNX1, and GATA3, described also in acute myeloid leukemia, are deleted or inactivated in ETP-ALL, and correlate with poor outcome: ETV6 (12p13) mutations account for ~25% of ETP-ALL (56), whilst RUNX1 (21q22), and GATA3 (10p14) mutations are less common. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.