LGALS9 and acute myeloid leukemia: In order to escape immune surveillance, AML blasts downregulate major histocompatibility complex (MHC) class I and II expression (29–32) and express inhibitory ligands such as programmed death-ligand 1(PDL-1), B7-H3 (CD276), and Galectin 9 (Gal-9) (33–35).