F2R and cancer: We also noticed that both specific DEGs in OE and DIE enriched in ‘pathways in cancer’, though enriched genes were different: DIE was associated with the risk of malignant transformation by enriched genes COL4A3, COL4A6, RAD51, F2R, PTGER3, while OE mainly by those PI3K pathway-related genes, such as FN1, GNG2, KIT, PTGS2, PDGFRA, LPAR1, CCND1, ITGA6, FGFR3, VEGFA, PIK3R1, FGFR2, MET.