Here we study the effect of albumin on HepG2/C3A hepatocellular carcinoma cell line, a contact inhibited subclone of the HepG2 cell line (Aden et al., 1979) that retains some physiological functions of normal hepatocytes (Kelly et al., 1992; Nibourg et al., 2012). This evidence concerns the gene ALB and hepatocellular carcinoma.