Other researchers also have shown that AMPKα2 is ubiquitinated by ubiquitin-conjugating enzyme E2O (UBE2O) in a mouse model of breast cancer, which activates the mammalian target of rapamycin-hypoxia inducible factor 1-α (mTOR-HIF1-α) pathway and triggers cancer growth [55]. This evidence concerns the gene PRKAA2 and cancer.