Additionally, persistent hyperglycemia is believed to induce neuroinflammation and neuronal damage as the glycosylation of myelin protein causes monocyte, neutrophil and macrophage infiltration, which in turn secrete the inflammatory cytokines, such as IL-6, TNF-α, and NF-κB, to further damage myelin sheath and increase nerve excitability, thus leading to edema and neuroinflammation [23, 24]. This evidence concerns the gene TNF and Hyperglycemia.