XDH and breast cancer: The alkaloids from Alphonsea elliptica barks atherospermidine (IC50 = 46.3 μg/mL), liriodenine (IC50 = 7.7 μg/mL), N-methylouregidione (IC50 = 42.1 μg/mL), and kinabaline (IC50 = 50.7 μg/mL) (Figure 25) were described as possessing moderate inhibition of XO activity by Aldulaimi et al. In addition, the cytotoxicity on MCF-7 human breast cancer cells was evaluated, with determined IC50 values greater than 62.0 μg/mL [101].