IL6 and irritable bowel syndrome: We found that the level of IL-6 in the spinal cord of rats in the Model group was significantly upregulated when compared to the Normal group (P < 0.01, Figure 2(e)) suggesting that inflammatory cytokine IL-6 was involved in the process of spinal sensitization IBS visceral hypersensitivity induced by acetic acid which is in agreement with the previous reports on spinal sensitization of somatic pain [45].