S100A12 and coronary artery disorder: In the Rotterdam study, a prospective population-based investigation of 839 participants without CAD being followed for 10.6 years identified S100A12 elevation in the highest tertile as having 2.6-fold higher risk of developing CAD compared with participants in the lowest tertile (hazard ratio, 2.59; 95% CI 1.52-4.40) [82].