Levels for UC and CD were not statistically different (p = 0.246), demonstrating that fecal S100A12 did not differentiate between forms of IBD, but using a ROC curve cut-off value of 2.8 μg/g, fecal S100A12 discriminated between IBD and IBS, similar to fecal calprotectin and previous S100A12 findings [66, 67]. Here, S100A12 is linked to irritable bowel syndrome.