Given the heterogeneity of liver disease and the possible impact on long term outcome, each CVID patient should be screened for a possible liver impairment through biochemical (i.e., AST, ALT, ALP, γGT, and total protein and albumin) and morphological (i.e., ultrasonography, TE, and eventually CT or MRI) assessments that should be performed at regular intervals. The gene discussed is ALB; the disease is common variable immunodeficiency.