The effect of FGF9 was found to be opposite that of FGF2, which may be due to the inverse relationship between FGF9 expression and FGF2 expression, and FGF2 and FGF9 may act as physiological antagonists to mediate emotionality and vulnerability in mood disorders (Aurbach et al., 2015). The gene discussed is FGF2; the disease is mood disorder.