RAG could regulate the expression of inflammatory cytokines induced by influenza virus, especially by reducing the expression of Th1 cytokines IFN-γ and TNF-α and increasing the expression of Th2 cytokines IL-4 and IL-5. After RAG administration, cell migration and infiltration were similarly reduced. RAG had a pleiotropic effect on viral pneumonia. Here, TNF is linked to viral pneumonia.