Precaution should be taken when using NDGA as anti-cancer agent, considering that, in particular types of cancer such as malignant glioma, NDGA can inhibit caspase 8 and 3, poly(ADP-ribose)polymerase cleavage and consequent CD95L-mediated apoptosis (Wagenknecht et al., 1998). Here, FASLG is linked to cancer.