However, it should be noted that the disruption of the KEAP1/NRF2 interaction by NDGA might not represent a general mechanism for other KEAP1 substrates and therefore experimental work is needed, not only to establish mechanistic interactions but also to know if these proteins might be functional effectors underlining the anti-tumor and anti-inflammatory activities of NDGA. This evidence concerns the gene KEAP1 and neoplasm.