TARDBP and amyotrophic lateral sclerosis: Thus, misfolded aggregates of α-synuclein are found in PD, β-amyloid (Aβ) plaques and hyper-phosphorylated TAU neurofibrillary tangles in AD, huntingtin in HD, superoxide dismutase 1, and TAR DNA binding protein 43 (TDP-43) in ALS, etc. A growing body of evidence supports a connection between NDGA and amyloidosis.