NFE2L2 and obesity due to melanocortin 4 receptor deficiency: A recent study by Xue et al. (2013) revealed that ablation of Nrf2 gene in the adipocytes of leptin deficient ob/ob mice (ob/ob mice) results in an even more severe obesity phenotype than typical ob/ob mice, which is coupled with aggravated IR, hyperglycemia, and hypertriglyceridemia.