Recently, another study has confirmed that plin2-/- mice can prevent obesity by inhibiting PPARγ, SREBP-1, and SREBP-2 pathways to improve insulin sensitivity, relieve endoplasmic reticulum stress, and inhibit the expression of lipid-synthesis related proteins (Libby et al., 2016). Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.