Down-regulated proteins are mainly involved in Huntington's disease, oxidative phosphorylation, Parkinson's disease, non-alcoholic fatty liver disease, and myocardial contractile metabolic pathway (Figure 7A2), while in the WS/WF group, the differential proteins were mainly concentrated in PPAR, hypertrophic cardiomyopathy, arachidonic acid metabolism, fat digestion and absorption, and dilated cardiomyopathy metabolic pathway (Figure 7B). Here, PPARA is linked to Huntington disease.