Down-regulated proteins are mainly involved in Huntington's disease, oxidative phosphorylation, Parkinson's disease, non-alcoholic fatty liver disease, and myocardial contractile metabolic pathway (Figure 7A2), while in the WS/WF group, the differential proteins were mainly concentrated in PPAR, hypertrophic cardiomyopathy, arachidonic acid metabolism, fat digestion and absorption, and dilated cardiomyopathy metabolic pathway (Figure 7B). The gene discussed is PPARA; the disease is Parkinson disease.