Combined with the conclusion of Maeda (Maeda et al., 2005) that the lack of both FABP4 and FABP5 has a stronger protective effect on diet-induced insulin resistance, obesity, and atherosclerosis than any single lack, so we speculated that silibinin may also affect lipid transport through FABP5. The gene discussed is FABP5; the disease is obesity due to melanocortin 4 receptor deficiency.