In animal studies, such as in the 129S inbred strain of mouse (with a spontaneous, native truncation in the C-terminal of DISC1), L100 and Q31l mutations of the gene result in schizophrenia-like phenotypes (Clapcote and Roder, 2006; Clapcote et al., 2007; Niwa et al., 2010; Sultana et al., 2019). Here, DISC1 is linked to schizophrenia.