Therefore to understand the behavioral impact of DISC1 interactions with environmental insults, in the present study, we utilized a mouse model of schizophrenia (Jones et al., 2011) to test the effects of an environmental stressor (maternal separation) and/or pharmacological intervention (ketamine; Table 1) on the severity of behavioral phenotypes in genetically predisposed animals (with DISC1 mutation) compared with controls. Here, DISC1 is linked to schizophrenia.