DISC1 and Anxiety: However, when there is a combination of factors, we found that genetic background has the biggest influence as shown by reduced sociability and novelty in the DISC1 mutation background animals (Figures 1C,D), when compared with the same insults on the control background highlighted in terms of anxiety-like behavior, stress calls and habituation to ASR as well as PPI (Figures 1A, 4B, 5, 6).