A previous study reported that an HP diet induced arterial medial calcification and elevated FGF23 levels in animal models of CKD, and arterial calcification was strongly correlated with serum FGF23 levels even when serum phosphorus levels are normal, suggesting the possibility that FGF23 might play roles as a marker and/or mediator of vascular calcification8. The gene discussed is FGF23; the disease is chronic kidney disease.