Protein levels of mature IL-1β and cleaved caspase-1 were increased in colon tissues of Slco2a1-knockout mice treated with DSS, which led us to hypothesize that NLRP3 inflammasome activation might contribute to the exacerbation of DSS colitis in Slco2a1-deficient mice. The gene discussed is SLCO2A1; the disease is colitis.