The numbers of Ki-67 positive cancer cells were significantly lower in tumors from mice treated with axitinib than in tumors from controls in A2780 and RMG1 (Fig. 5D,E, p < 0.0001, and p < 0.0001, respectively), but not in a HeyA8-MDR mouse model (Fig. 5F). This evidence concerns the gene MKI67 and cancer.