We found variants at nine loci to associate with POP; five of which associate at genome-wide significance with POP, three that were previously associated with height (P < 1.4 × 10−5) at TXNDC5 (6p24.3), SLC12A2 (5q23.3) and LOXL1 (15q24.1) (Supplementary Data 19) and one at WT1 that associates with inguinal hernia (11p13) (Supplementary Data 18). This evidence concerns the gene TXNDC5 and Inguinal hernia.