Notably, our analysis further revealed that other RBPs including those known to be associated with ALS and/or stress granule formation, i.e., FMR1, hnRNPA1, hnRNPA2B1, and Matrin-3, also showed enrichment around differentially regulated alternatively spliced exons in the Tg mice (Supplementary Fig. 4–6. The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.