Furthemore, the SNPs rs196929 (ERN1), rs2374261 (RHEB), rs1109089 (RHEB), rs4396582 (RAPTOR) showed association with three oral phenotypes (dental caries, periodontitis, and periapical lesions) in our previous study from a different Dental Registry and DNA Repository cohort18. Here, ERN1 is linked to dental caries.