AARS1 and undetermined early-onset epileptic encephalopathy: As a pathogenic gene, mutations in AARS may cause Charcot-Marie-Tooth disease 2N (CMT2N), characterized by progressive weakness and atrophy (Latour et al. 2010), and early infantile epileptic encephalopathy-29 (EIEE29), characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis (Simons et al. 2015).