WEE1 and cancer: WEE1 upregulation is seen in a variety of human cancers and is inversely associated with prognosis in some models.11 12 Two separate kinomic screens in HNSCC identified WEE1 expression as a particularly strong determinant of cell survival,13 14 indicating that HNSCC may be a fruitful setting in which to investigate the clinical effects of WEE1 inhibition.