Heterozygous mutations that disrupt human TUBA1A are associated with severe brain malformations, termed tubulinopathies, suggesting that TUBA1A is critical for brain development (Keays et al., 2007; Kumar et al., 2010; Cushion et al., 2013; Aiken et al., 2017). This evidence concerns the gene TUBA1A and cerebral malformation.