To thoroughly evaluate molecular features of TCR that are important for driving repertoire selection over time following EBV infection, we used direct ex vivo deep sequencing of both TCR Vα and Vβ regions of CD8 T cells specific to two immunodominant epitopes, BRLF-1109 (YVL-BR) and BMLF-1280 (GLC-BM), isolated from peripheral blood during primary EBV infection (AIM) and 6 months later in convalescence (CONV). Here, CD8A is linked to Epstein-Barr virus infection.