We conclude that E4orf3 or track formation is not involved in this process, as it has been reported that even when PML is not redistributed to tracks, as in the case of an E4orf3-depleted virus, RCs still form in proximity to PML-NBs (33), and we still observe E2A/PML interactions in the absence of E4orf3 during infection. Here, PML is linked to infection.