The results showed that the expression of ANGPT2 in HCC tissues (IOD = 270.6 ± 29.36, n = 96) was higher than that in benign liver disease (BLD) tissues (IOD = 157.3 ± 34.9, n = 11) (Fig. 1d); ANGPT2 existed in the serum-exosomes of both HCC and BLD, and exosomal ANGPT2 isolated from serum in HCC (756.5 ± 20.3 pg/mL, n = 67) was significantly higher than that in BLD (541.3 ± 18.82 pg/mL, n = 26) (Fig. 1e, f). The gene discussed is ANGPT2; the disease is hepatocellular carcinoma.