ANGPT2 and hepatocellular carcinoma: Additionally, we found that ANGPT2-overexpressing exosomes dramatically promoted HUVEC angiogenesis, and compared with control exosomes, ANGPT2-deficient exosomes abrogated exosome-induced angiogenesis (Fig. 5; Additional file 8: Figure S5), indicating that HCC cell-secreted exosomal ANGPT2 promotes angiogenesis.