ANGPT2 and neoplasm: In addition, the levels of tumor angiogenesis-related proteins CD31, CD105 and VEGFA in HUVECs were all obviously increased after coculture with ANGPT2-overexpressing exosomes, and compared with control exosomes, ANGPT2-deficient exosomes abrogated exosome-induced increases of these angiogenesis-related proteins (Fig. 5d).