ACT-1 (Traf3ip, Ciks) contains a helix-loop-helix motif at its N terminus and a coiled-coil at the C terminus, and it plays a negative role in autoimmunity through its differential impacts on both CD40-CD40L and BAFF-mediated pathways [87, 88]. Here, TRAF3IP2 is linked to Autoimmunity.