The treatment with CyA restored the abundance of 3 proteins at 1% oxygen to a level similar to that in cells grown at 19% oxygen, selenocysteine-specific elongation factor (EEFSEC), Bardet-Biedl syndrome 12 protein (BBS12) and breast cancer anti-estrogen resistance protein 3 (BCAR3). The gene discussed is BBS12; the disease is breast cancer.