CEACAM5 and gastric cancer: For instance, the ROC-AUC obtained with miR-421, a miRNA which is overexpressed in GC, targeting E-cadherin and caspase-3, thereby enhancing metastasis and attenuating apoptosis [74], is 0.77, with a positive detection rate of 72.5%, much higher than that of CEA, one of the most conventional tumor markers.