INS and Alzheimer disease: The patients were poly-medicated with three primary types of drug families (Table S2), i.e., oral anti-diabetics (AD) (mainly metformin, but also with different combinations of glucusorics and insulin sensitizers), lipid-lowering drugs (LL) (mainly statins, but also fibrates and ezetimibe), and anti-hypertensive drugs (HP) (mainly angiotensin II receptor blockers, angiotensin-converting enzyme inhibitors, as well as diuretics, calcium channel blockers, and β-1 adrenergic blockers).