CXCL8 and irritable bowel syndrome: We observed that sCD163 and IL-8 levels were significantly increased in IBD patients compared to those with IBS, while among patients with IBD, serum zonulin levels were significantly different between patients in clinical remission and those with active disease (43.6 (95% CI 20.4–46.4) ng/mL vs. 47.4 (95% CI 43.6–48.9) ng/mL, p = 0.035) (Figure 1).