Oct1-3 (Slc22a1-3), Octn1 (Slc22a4), Oat1, Oat3 and Rst (Slc22a12) knockout (KO) mice are fertile, viable and show no general phenotypic abnormalities except for the Oat3 KO’s decreased blood pressure, serum metabolite changes, and the Octn1 KO’s increased susceptibility to intestinal inflammation [6,16,17,20,21,22,23,24,25]. Here, SLC22A8 is linked to inflammatory response.