LTF and cancer: Taking all these evidences together, it is clear that the use of Lf as a cargo molecule for cancer therapy is sustained by several advantages: i) high stability and resistance to proteolysis which makes it suitable for NPs preparation and long-term storage; ii) null or low antigenicity when intravenously infused; iii) great selectivity for cancer cells due to the overexpression of its target receptors on their plasma membrane; iv) anti-cancer properties which can markedly improve chemotherapy efficiency; and v) proven safety even at high dosage.