The inflammatory participants to cancer microenvironment principally involve leukocytes, including dendritic cells, neutrophils, and macrophages, as well as lymphocytes, all able to secrete various inflammatory mediators, such as cytokines, cytotoxic molecules, including ROS and soluble mediators of cell killing, such as TNF-α and interferons (IFNs) [183]. Here, TNF is linked to cancer.