Over the 1970s and 1980s, several different functions have been ascribed to Lf, including antibacterial, antimicrobial, and immunomodulatory abilities, yet it was only in 1994 that Bezault and coworkers presented convincing data about the anti-cancer activity of hLf in murine models of fibrosarcoma and melanoma [102]. This evidence concerns the gene HLF and cancer.