The Lf preventive effect has been demonstrated in several animal models bearing different types of tumors, including lung, tongue, esophagus, liver, and colorectal [110,111,112,113], whereas Lf treatment was found efficient in inhibiting growth, metastasis, and tumor-associated angiogenesis [18,114,115], as well as in boosting chemotherapy [116,117]. This evidence concerns the gene LTF and neoplasm.