Upregulations of PRNCR1 (prostate cancer non-coding RNA1) occurred in prostate cancer (PC), and precancerous lesions PINs (prostatic intraepithelial neoplasia) and knockdown of PRNCR1 reduced the survival of PC cells and the expression of androgen receptor (AR), indicating an important role of PRNCR1 in facilitating PC via AR signaling (Table 1) [46]. The gene discussed is AR; the disease is prostate cancer.