Analyses of the TCGA datasets revealed that the mRNA levels of stem cell-related and MES-associated genes were significantly elevated in all subtypes of glioblastoma patients compared to normal brain tissue (Figure S2B) and were associated with a decreased survival rate of glioblastoma patients (Figure S2C), suggesting the important role of STAT3 in tumor malignancy, recurrence and drug resistance by maintaining CSC properties and enhancing metastatic capabilities in glioblastoma. This evidence concerns the gene STAT3 and glioblastoma.