In addition, ODZ10117 also effectively inhibited IL-6-induced STAT3 activation in glioblastoma and primary glioblastoma cell lines expressing lower level of active-STAT3 (Figure 2D and Figure S1C), and the inhibitory efficacy of ODZ10117 with the known STAT3 inhibitors and AG-490 was similar to that of glioblastoma and primary glioblastoma cell lines expressing higher levels of active STAT3 (Figure 2E and Figure S1D). Here, STAT3 is linked to glioblastoma.