In addition, ODZ10117 also effectively inhibited IL-6-induced STAT3 activation in glioblastoma and primary glioblastoma cell lines expressing lower level of active-STAT3 (Figure 2D and Figure S1C), and the inhibitory efficacy of ODZ10117 with the known STAT3 inhibitors and AG-490 was similar to that of glioblastoma and primary glioblastoma cell lines expressing higher levels of active STAT3 (Figure 2E and Figure S1D). This evidence concerns the gene IL6 and glioblastoma.