A meta-analysis evaluated the prognostic value of NME1 in patients with digestive system neoplasms (including patients with HCC and gallbladder cancer, but not CCA) and reported that high NME1 levels are correlated with well-differentiated tumors and with less-severe cancer stages, with no evident correlation with prognosis [53]. This evidence concerns the gene NME1 and cholangiocarcinoma.