Regarding the differential identification of CCA and PSC, the mRNA transcripts CAP-Gly domain containing linker protein 3 (CLIP3), Vascular cell adhesion molecule 1 (VCAM1) and Tripartite motif containing 33 (TRIM33) displayed excellent AUC values (0.965), in parallel with the pseudogene ATP synthase F1 subunit epsilon pseudogene 2 (ATP5EP2), the lncRNA LOC100134713, and the Small nucleolar RNA, H/ACA box 8 (SNORA8) (AUC: 0.939, 0.930, and 0.922, respectively), thus allowing to distinguish patients with CCA and PSC with high sensitivity and specificity values (Figure 7B). The gene discussed is ATP5F1EP2; the disease is cholangiocarcinoma.