TNF and obesity due to melanocortin 4 receptor deficiency: Obesity-associated adipocyte dysfunction by chronic inflammation in adipose tissue contributes to developing hepatic steatosis: (1) excessive free fatty acids from adipose tissue, which stimulate inflammation, could be delivered to liver; thus, triglycerides could be accumulated in liver; (2) adipose tissue secretes pro-inflammatory cytokines including TNF-α, which exacerbate inflammation in liver and induce hepatic steatosis [1].