Furthermore, the loss in monocyte/macrophage abundance was largely attributed to loss of inflammatory macrophages (Ptprc+/CD14+/Il1b+) that were reduced from 27.9% to 0.3% of the tumor, post-ex vivo culturing (Figure 8D), while anti-inflammatory and proliferating myeloid cells maintained comparable ratios in tumoroid cultures ~17.0% and ~3.4%, respectively. The gene discussed is IL1B; the disease is neoplasm.