In addition, increased cytosolic calcium levels, involved in the pathogenesis of AD, regulate glycogen synthase kinase, protein kinase C, and other kinases that hyperphosphorylate tau, potentiate NFT formation [30] and also facilitate the formation of Aβ peptides through calcium-mediated β-secretase activity [31,32,33,34,35]. Here, MAPT is linked to Alzheimer disease.