Our data reveal the presence of a pervasive anti-FATE1 immune response in ACT, confirm and extend the prognostic value of FATE1 expression in ACC and highlight a robust set of directly and inversely FATE1-coregulated genes in ACC gene expression profiles, which are enriched in transcripts involved in steroidogenesis and immune response, respectively. This evidence concerns the gene FATE1 and adrenal cortex carcinoma.