BRAF and colorectal carcinoma: Histological and molecular classifications of CRC do not perfectly overlap, since another subtype of SAC, termed “classical serrated CRC”, has been proposed that belongs to the CMS1 subtype and is characterized by BRAF mutation, CIMP, microsatellite instability (MSI), higher immune response and better prognosis than the “mesenchymal” SAC type [23].