Il-1β as a pro-inflammatory cytokine has already been studied as a possible biomarker in Alzheimer’s disease by different research groups, and although there were differences in the concentrations found, the common trend was that there was an increase in the concentration of this pro-inflammatory cytokine to confirm that in concomitance with protein aggregations there was inflammation in the brain that was also found in peripheral fluids [62,63,64]. The gene discussed is IL1B; the disease is early-onset autosomal dominant Alzheimer disease.