CXCL10 and lupus nephritis: In fact, Sundararaj et al. reported that FLi-1 impacts MRL/lpr lupus nephritis through direct regulation of chemokine (C-X-C) motif receptor 3 (CXCR3) to reduce T cell activation, migration, and downregulation of CXCR3 ligands, Cxcl9 and Cxcl10 in the kidney [29].